Momordica charantia as alternative therapy in veterinary medicine
DOI:
https://doi.org/10.22579/22484817.601Keywords:
Momordica charantia, phytopharmacology, phytochemical analysis, secondary metabolitesAbstract
In order to further our understanding of phytopharmacology Colombia, particularly those present in the eastern plains region, the species was chosen for further Momordica charantia in chemical composition and thus establish a potential medical utility. This analysis was performed preliminary phytochemical, which evaluated the presence of the main groups of secondary metabolites associated with biological activity, namely: alkaloids, flavonoids, triterpenoids, anthracene glycosides, cardiogenic glycosides and saponins. Was detected the presence of alkaloids in Momordica collected at the University of the Llanos, these compounds are widely known for their antidiabetic properties. It is also remarkable the presence of triterpenes, which are attributed antiparasitic properties, anticancer, anti-HIV, antidiabetic and antifeedant. It also showed the presence of cardiogenic glycosides that may have antiviral activities. The results of this work are really useful as a first approximation to the extension of chemical knowledge and the potential use fullness of the species in this area of Colombia, with medicinal properties to human health and animal-that allow the efficient use of resources country's natural as a source of regional and national development.
References
Ahmed M. S., Calle, J. Reportes manual de laboratorio de farmacognosia y fitoquímica. Departamento de farmacia de la Universidad Nacional de Colombia. Bogotá. 2005.
Almeida. DE. Plantas medicinais brazileiras, Conhecimentos populares e científicos. Hemus Editora Ltda. Sao Paulo. 1993.
Brandão, M.G., Zanetti, N., Oliveira, P., Grael, C.F., Santos, A.P., Monte-Mór L.M. Brazilian medicinal plants described by 19th century European naturalists and in the Official Pharmacopoeia. Journal of Ethnopharmacology, 120: 141-48. 2008.
Chang, C. I., Chen, C. R., Liao, Y. W., Cheng, H. L., Chen, Y. C., Chou, C. H. Cucurbitane-type triterpenoids from Momordica charantia. Journal of Natural Products, 69: 1168-1171. 2006.
Cheng, H. L., Huang, H. K., Chang, C. I., Tsai, C. P., Chou, C. H. A cell-based screening identifies compounds from the stem of Momordica charantia that overcome insulin resistance and activate AMP-activated protein kinase. Journal of Agricultural and Food Chemistry, 56: 6835-6843. 2008.
Chen, J., Tian, R., Qiu, M., Lu, L., Zheng, Y., Zhang, Z. Trinorcucurbitane and cucurbitane triterpenoids from the roots of Momordica charantia. Phytochemistry, 69, 1043-1048. 2008.
Coee, FG., Anderson, GJ. Ethnobotany of the Garifuna of Eastern Nicaragua. Econ Bot, 50 (1): 71-107. 1996. Sch Pharm Univ Connecticut Storrs Ct 06268 USA.
Giron, L.M., Freire, V., Alonzo, A., Caceres, A., Ethnobotanical survey of the medicinal flora used by the Caribs of Guatemala. Journal of Ethnopharmacology, 34: 173-187. 1991.
Harinantenaina, L., Tanaka, M., Takaoka, S., Oda, M., Mogami, O., Uchida, M., Asakawa, Y., Momordica charantia constituents and antidiabetic screening of the isolated major compounds. Chemical and Pharmaceutical Bulletin, 54: 1017-1021. 2006.
Husain, J., Tickle, I.J., Wood, S.P., Crystal structure of momordin, a type I ribosome inactivating protein from the seeds of Momordica charantia. FEBS Letters, 342: 154-158. 1994.
Khanna, P., Jain, S. C., Panagariya, A., Dixit, V. P. Hypoglycemic activity of polypeptide-p from a plant source. Journal of Natural Products, 44: 648-655. 1981.
Lans, C., Brown, G. Observations on ethnoveterinary medicines in Trinidad and Tobago. Preventive Veterinary Medicine, 35: 125-142. 1998.
Lans, C., Turner, N., Brauer, G., Lourenco, G., Georges, K. Ethnoveterinary medicines used for horses in Trinidad and in British Columbia, Canada. Journal of Ethnobiology and Ethnomedicine, 2: 31. 2006.
López LT. Plantas medicinales con actividad hipoglicemiante. Características, administración y efectos adversos. 25 (5). 2006.
Lotlikar, M. M., Rajarama Rao, M. R. Pharmacology of a hypoglycaemic principle isolated from fruit of Momordica charantia Linn. Industrial Journal of Pharmacology, 28: 129-133. 1966.
Mejia, K., Rengifo, E. Plantas medicinales de uso popular en la amazonia peruana. Aeci And IIap. Lima. 1995.
Miyahara, Y., Okabe, H., Yamauchi, T. Studies on the constituents of Momordica charantia L. II. Isolation and characterization of minor seed glycosides, Momordicosides C, D, and E. Chemical and Pharmaceutical Bulletin (Tokyo) 29: 1561-1566. 1981.
Murakami, T., Emoto, A., Matsuda, H., Yoshikawa, M., Medicinal foodstuffs. Part XXI. Structures of new cucurbitane-type triterpene glycosides, goyaglycosides-a, -b, -c, -d, -e, -f, -g, and -h, and new oleanane-type triterpene saponins, goyasaponins I, II, and III, from the fresh fruit of Japanese Momordica charantia L. Chemical & Pharmaceutical Bulletin (Tokyo), 49: 54-63. 2001.
Okabe, H., Miyahara, Y., Yamauchi, T., Miyahara, K., Kawasaki, T. Studies on the constituents of Momordica charantia L. I. Isolation and characterization of momordicosides A and B, glycosides of a pentahydroxy-cucurbitane triterpene. Chemical and Pharmaceutical Bulletin (Tokyo), 28: 2753-2762. 1980.
Okabe, H., Miyahara, Y., Yamauchi, T. Studies on the constituents of Momordica charantia L. IV. Characterization of the new cucurbitacin glycosides of the immature fruits. (2). Structures of the bitter glycosides, momordicosides K and L. Chemical and Pharmaceutical Bulletin (Tokyo), 30: 4334-4340. 1982.
Parkash, A., Ng, T.B., Tso, W.W., Purification and characterization of charantin, a napin-like ribosome-inactivating peptide from bitter gourd (Momordica charantia) seeds. Journal of Peptide Research, 59: 197-202. 2002.
Raman, A., Lau, C. Anti-diabetic properties and phytochemistry of Momordica charantia L. (Cucurbitaceae). Phytomedicine, 2: 349-362. 1996.
Sanabria A. Análisis fitoquímico preliminar. Universidad Nacional de Colombia, Facultad de Ciencias, Departamento de Farmacia, Bogotá,1-61. 1983.
Satyawati, G.V., Gupta, A.K., Tandon, N., Medicinal plants of India. Indian Council of Medical Research, New Delhi, India, 262 p. 1987.
Taylor, L. Technical data report for bitter melon (Momordica charantia). En: Herbal Secrets of the Rainforest. 2nd edition Sage Press. 2002.
USDA. National Nutrient Database for Standard Reference, Release 21. 2008. Disponible en: http://www.nal.usda.gov/fnic/foodcomp/cgi-bin/list_nut_edit.pl/
Xie, H., Huang, S., Deng, H., Wu, Z., Ji, A., Study on chemical components of Momordica charantia. Zhong Yao Cai. 21: 458-459. 1998.
Yasuda, M., Iwamoto, M., Okabe, H., Yamauchi, T. Structures of momordicines I, II, and III, the bitter principles in the leaves and vines of Momordica charantia L. Chemical and Pharmaceutical Bulletin (Tokyo), 32: 2044-2047. 1984.
Yen, G. C., Hwang, L. S. Lycopene from the seeds of ripe bitter melon (Momordica charantia) as a potential red food colorant. II. Storage stability, preparation of powdered lycopene and food applications. Journal of Chinese Agricultural Chemical Society, 23: 151-161. 1985.
Yesilada, E., Gurbuz, I., Shibata, H. Screening of Turkish antiulcerogenic folk remedies for anti-Helicobacter pylori activity. Journal of Ethnopharmacology 66, 289-293. 1999.
Yuan, Y.R., He, Y.N., Xiong, J.P., Xia, Z.X. Three-dimensional structure of beta-momorcharin at 2.55 A resolution. Acta Crystallographica Section D-Biological Crystallography, 55: 1144-1151. 1999.
Zamora M. Medicinal plants used in some rural populations of Oaxaca, Puebla and Veracruz, Mexico. J Ethnopharmacol, 35 (3): 229-257. 1992. Cent Inv Forest Agrop Dis Fed Mexico 04110 México.
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